Hormone Replacement Therapy: A New Era of Safety and Empowerment for Menopausal Women

Written by:
Dr. Lisa Harlan
July 2, 2025

If you’re a woman navigating menopause, you’ve likely heard conflicting information about hormone replacement therapy (HRT) — especially if you’ve heard the name "Women's Health Initiative" (WHI) tossed around. Decades ago, the WHI study led many to believe that HRT was unsafe, with concerns about heart disease, stroke, and breast cancer. Many women and even practitioners still believe that HRT is unsafe. 

But here’s the good news: our understanding has evolved, and HRT is now considered safe for most women, especially those who are recently post-menopausal or in early menopause transition. If you’re a woman seeking physical therapy for joint pain, muscle weakness, or other menopause-related concerns, understanding the current research on HRT can have a significant impact on your recovery and quality of life.

Why the Women’s Health Initiative (WHI) Study Changed the Game

The WHI, conducted in the early 2000s, caused widespread alarm when it reported that HRT might increase the risks of breast cancer, heart disease, and stroke. However, the study had limitations that are now more fully understood:

  • Age of Participants: The average age of women in the WHI was 63, often far beyond the typical onset of menopause. Many women in the study had pre-existing health conditions, which didn’t represent the health status of the general population entering menopause.
  • The Type of HRT Used: The study used a specific form of hormone therapy that included a combination of estrogen and synthetic progestin, which may not have been ideal for all women.
  • Overgeneralization: Results were widely interpreted as applying to all women, regardless of when they began HRT or their individual health histories.

These limitations have led to a new, more nuanced understanding of HRT. Today, most experts agree that HRT is safe for many women in early menopause, particularly when it’s started soon after menopause and tailored to an individual’s needs.

The Benefits of HRT for Women in Physical Therapy

If you’re undergoing physical therapy during menopause or perimenopause, the hormonal changes that come with this life stage can affect your body in many ways, including:

  • Muscle and Joint Pain: The drop in estrogen during menopause can lead to increased muscle and joint pain, especially in areas like the hips, knees, and lower back.
  • Bone Health: Estrogen is crucial for maintaining bone density. As estrogen levels decline, many women become at higher risk for osteoporosis and fractures.
  • Mood and Sleep Disruptions: Hot flashes, night sweats, and changes in mood can make it difficult to stick to a physical therapy regimen, especially if sleep is disrupted or pain is significant.

HRT can help manage these menopause-related symptoms, making it easier to stay active, recover from therapy sessions, and improve your overall physical health.

The Latest Research: HRT for Women Under 60 (or within 10 Years of Menopause)

When used appropriately, HRT is now considered safe for most women, particularly those who are within 10 years of menopause or under 60 years old. The current guidelines, from groups like the North American Menopause Society (NAMS) and the American College of Obstetricians and Gynecologists (ACOG), emphasize that starting HRT close to menopause has numerous benefits:

  • Reduced Bone Loss: HRT helps prevent the bone density loss that accelerates in menopause, reducing the risk of fractures, particularly in weight-bearing joints like the hips and spine.
  • Improved Muscle Function: By stabilizing estrogen levels, HRT can help maintain muscle strength, improving recovery from physical therapy exercises.
  • Reduced Joint Pain: Some women experience less joint pain and stiffness after starting HRT, making it easier to engage in physical activity and maintain joint mobility.
  • Better Sleep & Mood: Restful sleep and stable mood are essential for successful rehabilitation. By reducing menopause symptoms, HRT may improve your overall physical and mental well-being, which can contribute to a better therapy experience.

What You Should Know About HRT Today

While it’s true that some risks come with HRT (such as a small increased risk of breast cancer for women using combined estrogen and progestin), the benefits often outweigh these risks for women under 60 or within 10 years of menopause, especially when the therapy is personalized. Newer, safer options are available, including lower-dose estrogen, transdermal patches, and bioidentical hormones. It’s very important to find a provider who will test your hormones prior to starting HRT, then continue to monitor your levels to make sure you are receiving the optimal dosing.

If you're working with a physical therapist to address pain, stiffness, or weakness due to menopause, consider discussing HRT with your healthcare provider. By combining the benefits of hormone therapy with a structured physical therapy plan, you can potentially enhance your recovery, alleviate menopause-related discomfort, and improve your quality of life.

Conclusion: Empower Your Health and Recovery

If you are a woman nearing or in the menopause transition, understanding the evidence around HRT can be vital to your health and well-being. HRT can provide significant relief to symptoms like hot flashes, poor sleep, brain fog, and weight gain. Speak with your healthcare provider to see if you are a good candidate for HRT. 

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Disclaimer:  The views expressed in this post are based on the opinion of the author, unless otherwise noted, and should not be taken as personal medical advice. The information provided is intended to help readers make their own informed health and wellness decisions.

Dr. Lisa Harlan

Physical Therapist
Lisa Harlan is a Doctor of Physical Therapy (DPT) and Nationally Certified Pilates Teacher (NCPT) who specializes in orthopedics, women's health, and cancer rehabilitation. As a former professional ballet dancer, she has a passion for helping dancers and other individuals recover from injury and move well without pain. She works at Activcore in Atlanta, Georgia, located just 2 miles from Emory University.
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If you’re a woman navigating menopause, you’ve likely heard conflicting information about hormone replacement therapy (HRT) — especially if you’ve heard the name "Women's Health Initiative" (WHI) tossed around. Decades ago, the WHI study led many to believe that HRT was unsafe, with concerns about heart disease, stroke, and breast cancer. Many women and even practitioners still believe that HRT is unsafe. 

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